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10.3 A Quick Risk Primer in Statistics for Risk Management 1 1 Var(X ) = (0 ( 1))2 + (0 1)2 = 1 2 2 SD(X ) = 1 = 1

frequently a feature value occurs in the case base, the higher the probability that it is relevant to the new problem. Subsequently, with the help of adaptation knowledge (including case-speci c adaptation rules and the general knowledge base), the corresponding adaptation strategy can be determined. For those features whose relevance is above a given threshold, no adaptation is needed. On the other hand, for those features whose relevance is below a given threshold, adaptation is carried out to create the nal diagnosis for the patient. In general, arti cial neural networks (ANNs) are useful in medical case matching, selection, and retrieval, especially when there is insuf cient domain knowledge or relevant information. However, the user needs to consider the resources required for successful training of the ANNs. Other approaches, such as k-NN (k-nearest neighbor) and RBS (rule-based system), may be feasible alternatives if the domain knowledge is or can be made available. Another example of soft CBR application in medicine is the ELSI (error log similarity index) system [7,8]. It was developed to nd the error patterns automatically using diagnostic information from computed tomography (CT) scanners. The results are categorized and stored as cases that could be used by

The length of history of any of the three main features of a brain tumour is a guide to the nature of the tumour, in terms of malignancy. This is not foolproof, however. Certainly a long history suggests a benign or low-grade malignancy tumour. A short progressive history obviously implies malignancy, but sometimes a benign tumour can be silent for years only to produce a short worrying history when the brain and the intracranial compartments nally become unable to absorb the presence of the enlarging mass lesion.

The argument that even countries running trade deficits are better off because they get to consume a mix of goods and services they wouldn t get otherwise rests solely on the benefits of trading things that have already been produced But an even better argument for international trade is the fact that it actually increases the total amount of output produced in the world, meaning that more output per person results, and overall living standards rise This argument, known as comparative advantage, was developed by the English economist David Ricardo in 1817 as a forceful rebuttal against import tariffs known as the Corn Laws, which heavily taxed imports of foreign-grown grain at the time These laws kept the price of grain high, and so the nobility that owned the vast majority of farmland favoured retaining them.

several studies (Sinclair & Eales, 1972; Chatterjee & Bhattacharya, 1984; George & Young, 1986; Goks yr et al., 1987; James, 1988; Van Veld et al., 1990; Zhang et al., 1990; Leaver et al., 1992; Gadagbui & Goks yr, 1996). However, UDPGT and GST are also enzymes of multigene families, and comparatively less is known about their function and regulation in sh species (George, 1994). In addition to exposure to certain types of environmental pollutants, several other biotic and abiotic factors are known to in uence the cytochrome P450 monooxygenase system in sh. These include sex, reproductive status and steroid levels (F rlin & Hansson, 1982; Stegeman et al., 1982; Andersson, 1990; F rlin & Haux, 1990; Larsen et al., 1992; Arukwe & Goks yr, 1997), changes in season and temperature (Lindstr m-Sepp et al., 1985; Snegaroff & Bach, 1990; Lange et al., 1994; Sleiderink et al., 1995).

Naturally, the poor were opposed because the laws drove up the price of their basic food supply: bread Ricardo pointed out that abolishing restrictions on international trade would, in addition to helping England s poor, actually make England and all the countries it traded with richer by encouraging them to specialise in the production of goods and services that each of them was able to produce at the lowest possible cost He demonstrated that this process of specialisation would increase total worldwide output and thereby raise living standards The logic behind the comparative advantage argument is most easily understood by thinking in terms of people instead of countries Consider a patent lawyer named Heather and her brother Adam, who works as a bike mechanic Heather is very good at filing patents for new discoveries, but she s also very good at repairing bicycles.