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The comparison of SOM with hierarchical clustering methods shows that an SOM is superior in both robustness and accuracy [51] However, as K-means clusters, an SOM requires the value of parameter k to be prespeci ed RF clustering is based on an RF predictor that is a collection of individual classi cation trees After an RF is constructed, the similarity measure between two samples can be de ned as the number of times a tree predictor places the two samples in the same terminal node This similarity measure can be used to cluster gene expression data [52] It was demonstrated that the RF-based clustering of gene pro les is superior compared to the standard Euclidean distance measure [53] Other advanced techniques proposed for clustering gene expression data include the mixture model approach [54], the shrinkage-based similarity procedure [55], the kernel method [56], and bootstrapping analysis [57] 435.

Issues that must be decided include length of initial separation, time of evaluation and follow-up, continuing counseling, placement and visitation, child support and finances, whether to involve lawyers, how to tell the children, which individuals outside the family will be told about the separation and by whom and how, and whether the couple will see other people or remain monogamous The latter decisions can be the cause of much conflict and misunderstanding, and damage control can be prevented in therapy by clear ground rules These areas, of course, must also be addressed if and when the parties go on to a final divorce In this author s experience, a structured separation with counseling needs a minimum period of three months and is often six months to one year in length.

Multiple Access (CDMA) networks, and integration with corporate e-mail through the BlackBerry Enterprise Server (BES). The BlackBerry also was built upon a Java platform, which gave the product a robust foundation for secure communications, as well as a foundation to allow software developers to create add-on software applications and solutions. Since the introduction of BlackBerry, RIM s devices have grown in both popularity and functionality. Backed by large U.S. wireless carriers such as Sprint, Cingular, Verizon, and T-Mobile, as well as non-U.S. carriers such as O2, Orange, and Vodafone, the BlackBerry devices are now much more available and can easily be purchased through your preferred wireless carrier and added to your existing voice account. Today, according to published estimates, BlackBerry is supported by approximately 200 wireless carriers worldwide and has more than four million handheld customers, and BES is installed at more than 50,000 locations.

3 Distance of Gene Expression Pro le Clusters There are many ways to measure the distance between gene expression pro les and clusters of gene expression pro les The Pearson correlation coef cient and the Euclidean distance are often used for well-normalized microarray data sets However, microarray gene expression pro les contain noise and outliers Nonparametric distance measures provide a way to avoid these problems For instance, the Spearman correlation replaces gene expression values with their ranks before measuring the distance Average linkage, single linkage, and complete linkage are commonly used to measure the distances between clusters of gene expression pro les Average linkage.

CA SE ST U DY After 10 sessions of marital therapy focused on efforts to explore their differences and to solve their conflicts, Laura declared that she was tired of their repeated, unsuccessful efforts to fix the marriage She declared she wanted to separate and asked Michael to move out Michael was very reluctant and feared it would hasten a divorce, but tentatively agreed to a threemonth separation with the proviso that neither would date or see other people At this point, the therapist initiated a discussion of the meaning and purpose of the separation Their homework was to discuss and outline the ground rules of their separation Before the next scheduled session, the therapist received a phone call from a very anxious Laura who said that.